The importance of metal nanoclusters (MNCs) and their remarkable opto-physical properties as inorganic fluorescent quantum dots for bio-imaging and applications in medical diagnosis were studied. Their significance as good replacements for oftentimes, less-effective organic analogues was demonstrated. Silver and copper nanoclusters were prepared by reducing their metal ions with sodium borohydride in aqueous solutions. Atomic force microscopy results showed that silver and copper nanoclusters with an average size of approximately 1.40 nm were synthesized from their salts.