Human activities have immensely contributed to pollutants in water bodies such as heavy metals, organic and pathogenic microorganisms. This study was aimed to synthesize and investigate the aseptic efficacy of ZnO-carbonized zobo waste nanocomposite (ZOCZWNC) and Mg-Zn binary oxide (Mg-ZnBO) nanocomposite on Salmonella typhi – gram negative organism and Staphylococcus aureus – gram positive organism as well as removal of cadmium and nickel ions from contaminated water.