O. IYEKOWA

The leaves extracts of Telfairia occidentalis (Hook f) was studied as a potential antisickling agent. By solvent extraction, ethanol crude extract of leaves of Telfairia Occidentalis were partitioned to obtain their active fractions. In-vitro antisickling activity was determined using freshly prepared 2% sodium metabisulphite (negative control) and extracts of the plant (positive control) against haemoglobin SS red blood cell (HbSS). Activity- guided fractionation was used to target antisickling constituents of n-hexane fraction.

Medicinal plants are the first natural agents used traditionally to treat a wide range of illnesses, especially infectious diseases including malaria, diarrhea, fever, anaemia and colds especially in the rural areas. In this study, the calyxes of Hibiscus sabdariffa were investigated for their mineral composition, phyto constituents and oil components. Before extraction, twenty grammes (20g) of the powdered sample was analyzed for its mineral composition using X-ray fluorescence (XRF) spectrometry. The other part was extracted by cold maceration using methanol solvent.

Tetracarpidium conoforum, (family-Euphorbiaceae), root bark was investigated for its Phytoconstituents and chemical characterization by high performance liquid chromatography (HPLC). The root bark was extracted by hexane and concentrated for further analysis. A portion of the crude extracts recovered by rotary evaporator was screened for their phyto constituents using standard methods and the other portion isolated by vacuum liquid chromatograpy (VLC) was characterized by infra red spectroscopy and HPLC.